Bullmastiff
Lymphoma Study
Found a region associated with increased risk of lymphoma; risk for early onset lymphoma associated with a 1.2Mb on CFA13 containing 5 risk haplotypes and 4 candidate genes (MYC, miR=1204, miR-12-5, and miR-1206)
Found a region associated with increased risk of lymphoma; risk for early onset lymphoma associated with a 1.2Mb on CFA13 containing 5 risk haplotypes and 4 candidate genes (MYC, miR=1204, miR-12-5, and miR-1206)
- 20% of population has two copies of risk region, and 55% carry one copy.
Population Statistics
Mortlock et al 2016. Comparative analysis of genome diversity in Bullmastiff dogs. PLOS Jan 29, 2016.
From Australian pedigree database
142 founders
fe = 79
fa = 62
Ne(ref) = 41
From Australian pedigree database
142 founders
fe = 79
fa = 62
Ne(ref) = 41
Genetic Statistics
Data from DNA
0.345 (Dreger et al )
F = 0.0335
Ne = 29.1 (Mortlock)
H = 0.206 (Mortlock)
Lifespan
Cancer mortality
Median age at death (cancer)
