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SYLLABUS
DNA for Dog Breeders


Module 1 - Introduction to the course
  • Welcome to "DNA for Dog Breeders"
  • Why use DNA analysis?
  • What the course will cover
  • Who is the course for?
  • Course policies
 
Module 2 - Will DNA tests eliminate genetic disorders in dogs?
  • Can we test our way to healthy dogs?
 
Module 3 - DNA Nuts 'n Bolts
  • What is DNA?
  • Structure of DNA
  • Types of DNA
  • What is a chromosome?
 
Module 4 - How does DNA work?
  • DNA and genes
  • Genes and alleles
  • How do genes make proteins?
 
Module 5 - Types of mutations
  • Missense mutation
  • Nonsense mutation
  • Deletion
  • Insertion
  • Duplication
  • Frame shift
  • Copy number variation
  • Repeat expansion
 
Module 6 - Genetics of traits and diseases
  • Genotype determines phenotype
  • Monogenic traits
  • Polygenic traits
  • Complex traits
 
Module 7 - Types of DNA markers
  • What are markers?
  • Microsatellites
  • SNPs
  • DLA testing
  • Haplotypes and haplogroups
  • Other types of markers
 
Module 8 - DNA analysis
  • Whole genome sequencing
  • "Next generation" sequencing
 
Module 9 - Identifying genes for traits and diseases
  • Finding genes
  • GWAS
  • Association testing
 
Module 10 - DNA testing
  • How reliable are DNA tests?
  • Single mutation tests
  • Association tests
 
Module 11 - Choosing the right tests
  • What information do you need?
  • How will the information be used?
  • Other considerations (e.g., compatibility, obselescence)
  • What is most cost effective?
 
Module 121 - Who does DNA testing?
  • Single trait testing
  • Microsatellite-based genomics
  • SNP-based genomics
 
Module 13 - Using DNA information for traits & disorders
  • Understanding your report
  • Assumptions and limitations of tests
 
Module 14 - Using individual genomic data
  • Quantifying inbreeding
  • Verifying parentage
  • Visualizing DNA on the chromosome
 
Module 15 - Using population genomic data
  • Determining population genetic diversity
  • Determining relatedness and kinship
  • Determining effective population size
 
Module 16 - Breed composition
  • Breed verification and purity
  • Determining breed composition
  • Historical admixture
 
Module 17 - Breeding for traits and genetic health
  • Using DNA to improve genetic diversity
  • Genomic selection
  • Genetics of quantitative traits
  • Predicting litter phenotype
 
Module 18 - Population genetic structure
  • Identifying subpopulations
  • Determining genetic distance

Module 19 - Breeder tools
  • UC Davis Genetic Diversity Test
  • MyDogDNA Health Index
  • ICB Breeder Tool
  • Choosing the right tool to use
 
Module 20 - Software and other tools
 

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