The Institute of Canine Biology
  • HOME
  • Blog
  • Breed Preservation
    • Breeding for the future >
      • BFF Breed Groups
    • Breed Status
    • The "Elevator Pitch"
    • What's in the Gene Pool?
    • What population genetics can tell us about a breed
    • What population genetics can tell you...Tollers & Heelers
    • How to use kinship data
    • Using EBVs to breed better dogs >
      • How population size affects inbreeding
      • EBV Examples
    • How to read a dendrogram
    • Global Pedigree Project >
      • The Database
    • Finding the genes without DNA
    • How to read a heat map
  • Courses
    • COI BootCamp (FREE!)
    • Basic Population Genetics (FREE)
    • Genetic rescue: the genetics of cross breeding (NEW!)
    • The Biology of Dogs (Open Reg )
    • Managing Genetics For the Future >
      • Managing Genetics For the Future Open Reg (Open Reg) >
        • Syllabus - Managing Genetics for the Future
    • Genetics of Behavior & Performance (Open Reg)
    • Strategies for Preservation Breeding (Open Reg)
    • DNA For Dog Breeders (May2025) >
      • DNA For Dog Breeders (Open Reg)
    • Understanding Hip & Elbow Dysplasia (Open Reg) >
      • MORE FREE COURSES >
        • Quickie Genetics (Free!)
        • Group Discounts
        • Useful Genetics (Free!)
        • Strategies for Preservation Breeding (Sept 2023) >
          • Heredity & Genetics (Free!)
        • Basic Genetics Videos
  • Health Data
    • Bloat (Purdue Study)
    • Body Condition Score >
      • % Dysplastic vs BCS
    • Breed Comparions
    • Cancer
    • Cardiac
    • Cataracts
    • Caesareans
    • Deafness
    • Degenerative Myelopathy
    • Elbow Dysplasia
    • Epilepsy
    • Genetic Diversity
    • Genetic Diversity (MyDogDNA)
    • Hip Dysplasia >
      • Hip Dysplasia (Hou et al 2013)
    • Metabolic
    • Inbreeding Effects
    • Inbreeding (Gubbels)
    • Inbreeding (Dreger)
    • Lifespan
    • Litter size
    • mtDNA
    • Orthopedic
    • Mode of Inheritance
    • Patella Luxation
    • Thyroid
    • Portosystemic shunt
    • Purebred vs Mixed (UC Davis)
    • Purebred vs Mixed Breed (Bonnett)
    • Spay & Neuter Effects
    • Calboli et al 2008
    • Hodgman (1963)
    • Scott & Fuller (1965)
    • Stockard: Purebred crosses
    • Summers (2011)
  • Projects
    • How To Interpret Breed Analyses
    • Afghan Hound
    • More details about the Toller study
    • Belgian Tervuren >
      • Belgian Terv p2
      • Belgians- why population size matters
    • Bernese Mountain Dog
    • Boxer
    • Brussels Griffon
    • Bullmastiff
    • Canaan Dog >
      • Canaan analyses
    • Cesky Terrier >
      • Cesky genetic history
    • Chinook
    • Curly-coated Retriever
    • Doberman
    • Entelbucher Mountain Dog
    • Flatcoat Retriever
    • French Bulldog
    • German Shorthair
    • Golden Retriever >
      • Golden Retriever Pedigree Charts
    • Irish Water Spaniel >
      • IWS (6 Nov 17)
    • Labrador Retriever
    • Manchester Terrier
    • Mongolian Bankhar >
      • Research Updates
      • Bankhar 1
    • Norwegian Lundehund
    • Plummer Terrier
    • Otterhound
    • Portuguese Water Dog >
      • Portuguese Water Dog (pt 2)
    • Ridgeback
    • Schipperke
    • Standard Poodle >
      • The Problem With Poodles
      • 3poodle pedigree charts
      • 3Poodle Wycliff dogs
      • Poodle Genetics
    • Tibetan Spaniel
    • Tibetan Mastiff
    • West Highland White Terrier
    • Whippet
    • Wirehaired Pointing Griffons
    • UK KC Graphs >
      • UK KC Breed Status
      • UK Groups
      • KC Gundogs
      • KC Hounds
      • KC Terriers >
        • Terriers (select breeds)
      • KC Pastoral
      • KC Toys
      • KC Working
      • KC Utility
      • Australian KC
    • Breed outcrossing programs
  • Resources
    • Genetics Databases
    • Stud Books >
      • American Kennel Club stud books
      • Field Dog stud books
      • The Kennel Club (UK)
    • Learn
    • Videos about dog genetics
    • The Amazing Things Dogs Do! (videos) >
      • Livestock Management
      • Livestock guarding
      • Transportation, exploration, racing
      • Conservation & wildlife management
      • Detection Dogs
      • Medicine & Research
      • Entertainment
      • AKC/CHF Podcasts
    • Read & Watch
    • Bookshelf

How to breed dogs that are better than their parents: the genetics of continuous traits

1/19/2019

 
By Carol Beuchat PhD

The quantitative genetics of continuous traits
Through a series of clever experiments, Mendel opened the black box that held the secret of the gene, which he concluded was responsible for the inheritance of traits in plants and animals. Knowing this, breeders could do some simple breeding experiments to reveal whether the genes for particular traits were dominant or recessive, which allowed them to design breedings that produced predictable traits.

While this took some of the mystery out of breeding for many traits, for other traits prediction remained elusive, and breeders realized that in some cases the genetics of a trait must be more complex. The problem, of course, was that some traits are determined by many genes. How could breeders do selective breeding on these so-called polygenic traits to reliably produce particular traits?
Picture
The puzzle was finally solved by a university geneticist named Jay Lush. In the 1930s, Lush realized that, for many traits, there could be lots of variation from individual to individual in a trait. That is, some traits were not "binary".

​For instance, there could be a range of size in a population of cows from small to large and everything in between, and not just two (binary) sizes of large and small. He realized that this was the case for many traits and began to think about how genetics could account for this. What Lush had stumbled upon was the key to selective breeding for traits that can vary continuously - genetic variation.

He described this in his groundbreaking book, Animal Breeding Plans.
"Variation - differences between individuals - is the raw material on which the breeder works. It is not necessary that the animals vary widely enough that the breeder can at the very start find some perfect ones to select, but they must vary enough that some of them will be closer to his ideal than others are... The effects of a combination of genes in the individual equal the sum of the average effects of those genes." (Lush 1937)
​
Here, Lush is making the two observations that transformed animal breeding in the mid-1900s: 1) that genetic variation provides the raw material for selection, and 2) that some of this variation was "additive". Put another way, the effects of multiple genes acting on the same trait can be added. One large dog bred to another large dog could produce offspring larger than either parent.

This is what he is alluding to when he says that it's not necessary for a breeder to find the exact traits desired in a potential breeding animal, because genetic variation can be used to create a new mix of genes that will produce a trait not present in the current population. 
Lush's observation launched a new field of genetics, called "quantitative genetics", that was based in mathematics and statistics and applied specifically to traits that vary continuously. The advances in our understanding of quantitative genetics subsequently revolutionized animal breeding and was the basis of the spectacular improvements in production that became the modern system of commercial breeding of livestock and other animals.
One of the best examples of the gains that could be achieved by understanding the basis of additive genetic variation is for milk production in cattle. At the beginning of the 1900s, average milk yield was about 2,000 kg per year.There were no cows to be found anywhere that could produce 8,000 kg of milk per year. However, with the application of selection based on quantitative genetics in the 1940s, milk production soared and by 2000 it averaged more than 8,000 kg of milk per year - a four-fold increase in milk production over a period of about 50 years. Gains in production were made incrementally, a bit more each generation, and the basis for progress was finding advantageous combinations of genes that, added together, would push a trait in the desired direction. Breeders used the genetic variation in the animal population to create new combinations of genes in the next generation, then selected from among those animals the ones that improved on the trait over their parents.

There was one critical thing that was absolutely necessary for this to work: there needed to be genetic variation in the population. Breeders had to protect the genetic variation in their breeding stock, because without it new combinations of genes would not be possible and there would be nothing to select for.
​
Picture

The realization that selective breeding could produce animals that were superior to both parents revolutionized animal breeding. The use of additive genetic variation to produce animals with traits not present in the original breeding stock became the fundamental process of selective breeding in domestic animals.

Picture
Commercial breeders have leveraged additive genetic variation to produce chickens that grow faster, are larger as adults, and lay more eggs than the ancestral jungle fowl from which the modern chicken was domesticated.

Continuous variation in dogs
Of course, dogs provide many examples of traits that have been shaped by selective breeding that takes advantage of additive genetic variation.

Body size is an obvious one. Researchers have identified multiple genes that can be associated with variation in body size in dogs. Some of these have a large effect, accounting for a significant fraction of the variation in size. But there is still much variation that is not yet accounted for genetically, and there might be dozens or even hundreds of other genes that have tiny effects individually but collectively account for differences among individuals.
Let's look at another example.

People probably started racing dogs thousands of years ago, and it's fair to suspect that over this time there has been selection to improve speed. 
These are data for 1,000 racing dogs in Ireland over a distance of 480 meters (Taubert & Agena). Most dogs cover the distance in 29-30 seconds. But there is also much variation among individuals, from the slowest that took about 32.5 seconds, to the fastest at about 28 seconds.

There could be many reasons for this variation, including motivation, condition of the track on the day, and other enviromental factors. But at least some of this variation might be  attributed to genetics.

How could breeders use selection to breed faster dogs?
Picture
Results of 1000 dogs, shown in 1/10th of a second difference. The height of each bar shows the number of dogs belonging to the time below it.
One option would be to breed only the best to the best. Identify the sire and bitch with the fastest racing times and breed them together. Will some of the offspring be faster than either parent? Perhaps. Might some be slower? Perhaps. So what do we do from here?

We could mate the fastest male in the litter with the fastest female, and again select the fastest of their progeny. 

We might end up with dogs faster than the first two parents, but over the generations of inbreeding and strong selection (breeding only "best to best"), progress will start to level off. We will have eliminated much of the original genetic diversity in the dogs of the first generation. In fact, the puppies in each litter will share a larger and larger fraction of the same genes every generation. We are not going to get faster and faster dogs forever. Why? Apart from the deleterious effects of inbreeding, we have tossed out the genetic variation necessary to produce improvement in a continuous trait by exploiting additive genetic variation. We have bred ourselves into a dead end.
So how can you produce faster dogs from selective breeding and not run into this problem of a genetic dead end?

Redefine what you mean by "best". We do definitely want to select the best animals to breed, but we need to think of it in terms of the genetics of the population. To improve on a polygenic trait, we need genetic variation to select for. Instead of selecting a single best dog, we can select a subpopulation of dogs that are all faster than average. We will then use the genetic variation in those dogs, and the random inheritance of that variation in the offspring, to push racing performance in the direction of higher speed.


Picture
Taubert & Agena


Can we keep producing faster and faster dogs forever? Probably not. If we don't run out of genetic variation, at some point we will run up against the limits of design and physiology. But we can definitely use selective breeding in this way to improve most traits that are polygenic in dogs.
So think about this. What traits do you strive for that are polygenic? Size. Temperament. Working ability. Coat quality. Ear length. Muzzle length. Shoulder angulation. Intelligence. The list is long.

Note that there is another issue here that breeding in this way addresses. The phenotype of polygenic traits is likely to be a reflection not just of genetics, but also of a roster of non-genetic factors, some of which might be known but most will not. When you select only the "best" individual to breed, you are selecting for the combination of genes and environment that produced what you perceive to be best. But you really only want to be selecting based on genes, because only that part of a trait can be inherited. Maybe the fourth "best" dog has great genes for the trait you want but was raised in a less than ideal situation. That dog's genes will get tossed if you only select the single best animal. By breeding a subpopulation of the top performing dogs, you preserve the genetic variation you need for selection and also reduce the influence of non-genetic factors in your choice.
You have no doubt noticed that this method of breeding, where the "best" is defined as a subpopulation of individuals instead of a single dog, is not the way dog breeders usually breed. We usually choose to breed only the dog we perceive to be the "best", ignoring the possible effects of environment on our assessment of the other apparently-inferior dogs. Doing this, we narrow the gene pool and increase inbreeding every generation, both of which will limit our ability to continue to improve traits. This applies to health as well as physical and behavioral traits. We can't "breed around" health issues if the necessary genetic variation no longer exists in the population of breeding animals.  
Can we breed better dogs by taking advantage of additive genetic variation? Yes, by changing the way we define "best" during selection. The improvement we can achieve might be significant - in health, in physical traits of importance, in temperament, and many other traits that we care about. 

Let's breed better, healthier dogs. Learn about the quantitative genetics of continuous traits and how you can use this knowledge to your advantage in your breeding program.
​
REFERENCES
Taubert H & D Agena. Quantitative Traits. (no date, no publisher)
Lush, J.L. 1937. Animal Breeding Plans. 


To learn more about the genetics of dogs, check out
ICB's online courses

***************************************

Visit our Facebook Groups

ICB Institute of Canine Biology
...the latest canine news and research

ICB Breeding for the Future
...the science of animal breeding

Comments are closed.

    Archives

    January 2030
    February 2025
    January 2025
    December 2024
    November 2024
    October 2024
    July 2024
    June 2024
    May 2024
    March 2024
    February 2024
    July 2023
    April 2023
    November 2022
    July 2022
    May 2022
    April 2022
    March 2022
    February 2022
    November 2021
    October 2021
    December 2020
    January 2020
    August 2019
    July 2019
    June 2019
    May 2019
    April 2019
    March 2019
    February 2019
    January 2019
    December 2018
    November 2018
    September 2018
    August 2018
    July 2018
    June 2018
    May 2018
    October 2017
    August 2017
    May 2017
    April 2017
    March 2017
    February 2017
    January 2017
    December 2016
    November 2016
    September 2016
    August 2016
    July 2016
    June 2016
    April 2016
    March 2016
    February 2016
    January 2016
    December 2015
    November 2015
    October 2015
    September 2015
    August 2015
    July 2015
    June 2015
    May 2015
    April 2015
    March 2015
    January 2015
    December 2014
    November 2014
    October 2014
    September 2014
    August 2014
    July 2014
    June 2014
    May 2014
    February 2014
    December 2013
    October 2013
    September 2013
    July 2013
    March 2013
    July 2012
    April 2012

    Categories

    All
    Behavior
    Border-collie
    Herding

Blog

News


About Us

Contact Us








Copyright © 2012-2017 Institute of Canine Biology
Picture
Picture