By Carol Beuchat PhD
Rates of Mortality in Puppies
Neonatal mortality is a significant problem in dogs, with rates generally averaging from 5-30% (Gill 2001; Tonnessen et al 2012). After eliminating individuals with developmental abnormalities or other apparent issues, most of this mortality is due to uterine inertia, in which the strength and frequency of contractions are not sufficient to expel the puppy. This results in protracted labor, with the result that puppies run out of oxygen before birth, resulting in stillborn puppies that die of asphyxia. Some puppies are born live but physiologically compromised as a result of hypoxia during parturition; these may die in the days or weeks after birth.
The data in the table below are for the disposition of 2,574 puppies of 44 breeds that were produced by 125 breeders in Australia from 1991 to 1998 (Gill 2001). Most of the mortality in this cohort (61.5%) was due to puppies that were stillborn or died in the first 24 hours. About 65% of whelpings required no assistance for delivery, while dystocia occurred in 35.6%. Emergency cesareans were necessary for 18% of the litters. In 48.6% of the litters, there were no mortalities; 14.8% of litters had stillbirths, and in 6.6% the entire litter died, although about half of these were singleton litters.
 Gill 2001; Table 2.2 |  |
The charts below show data compiled from the records of the Swedish Kennel Club for 58,439 puppies from 10,810 liters whelped in 2006 and 2007 (Tonnessen et al 2012). The data are reported as 1) puppies that were stillborn and 2) as perinatal mortality (the percentage of all puppies born that did not survive past 7 days, including stillbirths). (Only breeds with data for at least 10 litters.)
What is evident in these data is the wide range of values across breeds. There are a few breeds in which stillborn or perinatal mortality is very low or did not occur in this sample (e.g., Basenji, German Spitz). But for most breeds, it is clear that puppy mortality is unacceptably high, even greater than 10% in many breeds.
What is evident in these data is the wide range of values across breeds. There are a few breeds in which stillborn or perinatal mortality is very low or did not occur in this sample (e.g., Basenji, German Spitz). But for most breeds, it is clear that puppy mortality is unacceptably high, even greater than 10% in many breeds.
Tonnessen et al, 2012
The exceptional rates of mortality in puppies have been a significant veterinary concern for several decades. While attributed to uterine inertia, the cause of uterine inertia has not been determined. Suggestions include uterine fatigue, over-stretching of the uterine muscle (e.g., from large litters), and inadequate levels of oxytocin. Treatment of uterine inertia generally involves administering calcium or oxytocin, although these have either limited effectiveness or none at all in improving uterine contractility and expulsion of puppies (Bergstrom et al 2006; Prashantkumar & Walikar 2018).
The relative rates of mortality of puppies might seem low (i.e., as a percentage of puppies produced). But the toll in number of puppies lost at birth or shortly thereafter is substantial. The mortality in Tonnessen's study represents deaths of 4,684 puppies over just the period from 2006 to 2007 in Sweden. That's a lot of puppies to lose, year after year after year in one country, but you have to appreciate that the toll worldwide would be in the many tens or hundreds of thousands.
With the cause of uterine inertia remaining undetermined, there are no recommended procedures for breeders to prevent the high rates of neonatal mortality. Without a cause for uterine inertia, it cannot be prevented, and the huge number of puppies that are perfectly formed but do not survive their first week in this world will continue to accrue.
The relative rates of mortality of puppies might seem low (i.e., as a percentage of puppies produced). But the toll in number of puppies lost at birth or shortly thereafter is substantial. The mortality in Tonnessen's study represents deaths of 4,684 puppies over just the period from 2006 to 2007 in Sweden. That's a lot of puppies to lose, year after year after year in one country, but you have to appreciate that the toll worldwide would be in the many tens or hundreds of thousands.
With the cause of uterine inertia remaining undetermined, there are no recommended procedures for breeders to prevent the high rates of neonatal mortality. Without a cause for uterine inertia, it cannot be prevented, and the huge number of puppies that are perfectly formed but do not survive their first week in this world will continue to accrue.
Uterine Inertia in Dogs is Caused by Light
While observing the whelping of litters of more than 50 breeds of dogs over the last few years, I have inadvertently discovered that uterine inertia in dogs appears to be caused by light.
When the whelping room was kept dark, bitches were calmer and more relaxed, and puppies were expelled easily and without straining. Visible abdominal contractions were infrequent. The intervals between puppies were generally short, ranging from 10-30 minutes. When darkness was maintained through whelping of the entire litter, there were no stillborn puppies or pups born in distress. The puppies were vigorous as soon as they were released from the membranes and were able to find and attach to teats without assistance. Between puppies, the bitch cared for the puppies but was relaxed and without signs of stress.
If the bitch was exposed to any light during whelping, as for example by turning on a light or even a cell phone, the appearance of the bitch changed. She appeared less relaxed and abdominal contractions began. This usually lasted for about two hours after the light event and the whelping room was again completely dark. All of the stillborn puppies we observed were born after periods of exposure of the bitch to light with one exception, in which the last puppy in a litter of 15 was stillborn.
When the whelping room was kept dark, bitches were calmer and more relaxed, and puppies were expelled easily and without straining. Visible abdominal contractions were infrequent. The intervals between puppies were generally short, ranging from 10-30 minutes. When darkness was maintained through whelping of the entire litter, there were no stillborn puppies or pups born in distress. The puppies were vigorous as soon as they were released from the membranes and were able to find and attach to teats without assistance. Between puppies, the bitch cared for the puppies but was relaxed and without signs of stress.
If the bitch was exposed to any light during whelping, as for example by turning on a light or even a cell phone, the appearance of the bitch changed. She appeared less relaxed and abdominal contractions began. This usually lasted for about two hours after the light event and the whelping room was again completely dark. All of the stillborn puppies we observed were born after periods of exposure of the bitch to light with one exception, in which the last puppy in a litter of 15 was stillborn.
I am not the first to observe that light shuts down uterine contractions during labor. In humans, contractions are suppressed if a light is turned on, and they resume when darkness is restored (Olcease 2015). This is so effective that there is a patented medical device designed to prevent premature labor by suppressing uterine contractions with light (Olcease 2015).
One human patient (Olcese 2015)
The Case for Whelping in the Dark
There is every reason to suspect that ambient light is the cause of uterine inertia during whelping in dogs. If this is true, the solution to high puppy mortality in dogs is management of light during the few hours when the bitch is whelping. My experiences controlling light during whelping indicate that this is the case.
It makes sense that the physiology of the dog is designed for whelping in the dark.
Wolves and free-living dogs whelp their puppies in underground dens, and the puppies remain in the den for several weeks. Our household pets seek out dark places as whelping nears, disappearing under the bed, in a closet, or behind a piece of furniture. We assume they are looking for a place that is protected, quiet, and cozy, and this might be true. But the key attraction for the dog might be darkness.
Nevertheless, bitches whelping in the house are typically provided a box in a location convenient for monitoring, such as a bedroom, family room area, or even by a window. Because breeders generally supervise and assist with whelping, lighting is at least sufficient for the breeder to see even if it is dim.
It makes sense that the physiology of the dog is designed for whelping in the dark.
Wolves and free-living dogs whelp their puppies in underground dens, and the puppies remain in the den for several weeks. Our household pets seek out dark places as whelping nears, disappearing under the bed, in a closet, or behind a piece of furniture. We assume they are looking for a place that is protected, quiet, and cozy, and this might be true. But the key attraction for the dog might be darkness.
Nevertheless, bitches whelping in the house are typically provided a box in a location convenient for monitoring, such as a bedroom, family room area, or even by a window. Because breeders generally supervise and assist with whelping, lighting is at least sufficient for the breeder to see even if it is dim.
This arrangement, however, is very unsuitable for whelping. With the ambient light suppressing uterine contractions, the bitch must expel the puppies with strong abdominal contractions instead. The result is inefficient and protracted labor, and the long intervals between births greatly increase the risk of stillbirth (Cornelius et al 2019).
The unintended consequence of the way we generally whelp puppies is that the difficulties encountered during labor that motivate close supervision by breeders are, in fact, caused by that very supervision, because it requires ambient light for the breeder to see. The best of intentions result in making whelping significantly more difficult.
But we should be able to dramatically reduce mortality of newborn puppies.
We need to give the bitch access to the conditions that her instincts tell her are best suited for whelping and raising her puppies, instead of what suits our convenience. The physiology of dogs and many other mammals is designed to give birth in the dark. We need to give her darkness.
This is routinely done by keepers of zoo animals, who carefully consider the biology and natural history of an animal in its natural environment in designing its habitat in captivity. Staff supervise by video and intervene if necessary, but, more often than not, birth proceeds without complication or intervention.
Dogs are quite good at reproducing themselves if left to their own devices. We should have fewer complications and much greater success with a simple strategy: just give her what she needs and get out of her way.
But we should be able to dramatically reduce mortality of newborn puppies.
We need to give the bitch access to the conditions that her instincts tell her are best suited for whelping and raising her puppies, instead of what suits our convenience. The physiology of dogs and many other mammals is designed to give birth in the dark. We need to give her darkness.
This is routinely done by keepers of zoo animals, who carefully consider the biology and natural history of an animal in its natural environment in designing its habitat in captivity. Staff supervise by video and intervene if necessary, but, more often than not, birth proceeds without complication or intervention.
Dogs are quite good at reproducing themselves if left to their own devices. We should have fewer complications and much greater success with a simple strategy: just give her what she needs and get out of her way.
Dark Whelping
We need a new approach to whelping dogs that is better suited to their biology. I am calling it "dark whelping".
Breeders are asking me questions about dark whelping:
Unfortunately, the answer to these questions like these is usually "I don't know".
The dark whelpings I have done have been in absolute darkness (i.e., can't see your hand in front of your face), because this is a light level that can be replicated by every breeder (as opposed to various unknown levels of dimness). Under these conditions, with total darkness and no unplanned "light events", our puppy mortality has been zero.
Total darkness is difficult to do in the typical household. It takes planning and working out critical bits of the logistics ahead of time (e.g., how to retrieve the puppies for weighing without introducing light to the whelping room). But we have been doing it with success, and the extra trouble over a more convenient whelping box in the living room or bedroom is well worth the prevention of mortality.
I can't provide you with a protocol to set up dark whelping yourself. Every breeder's setup is different, and there will be different issues to resolve for the ideal setup for each litter. I can tell you that the process seems to be extremely sensitive to light, and getting it wrong often results in dead puppies.
However, if you would like to whelp a litter in the dark, you can contact me for assistance. I have experience with enough litters now to have worked out at least some of the problems you are likely to encounter.
Breeders are asking me questions about dark whelping:
- How dark does it have to be?
- Does it need to be dark only during labor, or before (or after) as well?
- Is turning a light on very quickly okay?
- What about a really dim light?
- Is a red heat lamp ok to use?
Unfortunately, the answer to these questions like these is usually "I don't know".
The dark whelpings I have done have been in absolute darkness (i.e., can't see your hand in front of your face), because this is a light level that can be replicated by every breeder (as opposed to various unknown levels of dimness). Under these conditions, with total darkness and no unplanned "light events", our puppy mortality has been zero.
Total darkness is difficult to do in the typical household. It takes planning and working out critical bits of the logistics ahead of time (e.g., how to retrieve the puppies for weighing without introducing light to the whelping room). But we have been doing it with success, and the extra trouble over a more convenient whelping box in the living room or bedroom is well worth the prevention of mortality.
I can't provide you with a protocol to set up dark whelping yourself. Every breeder's setup is different, and there will be different issues to resolve for the ideal setup for each litter. I can tell you that the process seems to be extremely sensitive to light, and getting it wrong often results in dead puppies.
However, if you would like to whelp a litter in the dark, you can contact me for assistance. I have experience with enough litters now to have worked out at least some of the problems you are likely to encounter.
Creating a Protocol for Breeders
We have been whelping dogs for decades the same way, in a box in the house. We know nearly nothing about doing it in the dark beyond the fiddling I have done so far. For dark whelping, we will need research to nail down the necessary and sufficient conditions for success.
The sooner we can figure out how to do this right and provide breeders with a protocol they can follow, the sooner we can reduce the tragic loss of puppies that simply run out of oxygen before they make it out into the real world.
It won't take millions of dollars and many years to learn more about this. I just need breeders with upcoming litters and some financial support for my time to assist with logistics and guidance for breeders, and to record the outcome of a whelping event so I can prepare a protocol breeders can follow. There is lots of compelling research that will come out of this new information about whelping dogs, but for now my priority is to reduce puppy mortality as quickly as possible.
We can prevent puppy mortality from uterine inertia in your very next litter.
The sooner we can figure out how to do this right and provide breeders with a protocol they can follow, the sooner we can reduce the tragic loss of puppies that simply run out of oxygen before they make it out into the real world.
It won't take millions of dollars and many years to learn more about this. I just need breeders with upcoming litters and some financial support for my time to assist with logistics and guidance for breeders, and to record the outcome of a whelping event so I can prepare a protocol breeders can follow. There is lots of compelling research that will come out of this new information about whelping dogs, but for now my priority is to reduce puppy mortality as quickly as possible.
We can prevent puppy mortality from uterine inertia in your very next litter.
Research Project: Uterine Inertia and Neonatal Mortality in Dogs
You can learn more about our project to prevent uterine inertia and reduce puppy mortality in our Facebook group, Uterine Inertia and Neonatal Morality in Dogs.
If you are interested in supporting the development of a protocol for dark whelping that breeders can use to reduce puppy mortality, please contact me.
If you are interested in supporting the development of a protocol for dark whelping that breeders can use to reduce puppy mortality, please contact me.
REFERENCES
Bergstrom A, et al. 2006. Primary uterine intertia in 27 bitches: aetiology and treatment. J Small Anim Pract 47: 456-460.
Cornelius AJ et al. 2019. Identifying risk factors for canine dystocia and stillbirths. Theriogenology 128: 201-206.
Gill MA, 2001. Perinatal and late neonatal mortality in the dog. PhD Thesis, University of Sydney.
Olcese J, 2015. Using light to regulate uterine contractions. US Patent No US 8,992,589
Prashantkumar, KA and A Walikar. 2018. Evaluation of treatment protocols for complete primary uterine inertia in female dogs. Pharma Innov J 7:661-664.
Tonnessen R, et al. 2012. Canine perinatal mortality: a cohort study of 224 breeds. Theriogenology 77: 1788-1801.
Bergstrom A, et al. 2006. Primary uterine intertia in 27 bitches: aetiology and treatment. J Small Anim Pract 47: 456-460.
Cornelius AJ et al. 2019. Identifying risk factors for canine dystocia and stillbirths. Theriogenology 128: 201-206.
Gill MA, 2001. Perinatal and late neonatal mortality in the dog. PhD Thesis, University of Sydney.
Olcese J, 2015. Using light to regulate uterine contractions. US Patent No US 8,992,589
Prashantkumar, KA and A Walikar. 2018. Evaluation of treatment protocols for complete primary uterine inertia in female dogs. Pharma Innov J 7:661-664.
Tonnessen R, et al. 2012. Canine perinatal mortality: a cohort study of 224 breeds. Theriogenology 77: 1788-1801.
