The Institute of Canine Biology
  • HOME
  • Blog
  • Courses
    • COI BootCamp (FREE!)
    • Basic Population Genetics (FREE)
    • The Science of Canine Husbandry
    • Managing Genetics For the Future >
      • Syllabus - Managing Genetics for the Future
    • The Biology of Dogs (Open Reg )
    • DNA For Dog Breeders >
      • Syllabus - DNA for Dog Breeders
      • Open Reg - DNA For Dog Breeders
    • Understanding Hip & Elbow Dysplasia >
      • Open Reg - Understanding Hip & Elbow Dysplasia
    • Genetics of Behavior & Performance >
      • Syllabus - Genetics Behavior & Performance
      • Open Reg - Genetics of Behavior & Performance (Open Reg)
    • Strategies for Preservation Breeding >
      • Open Reg - Strategies for Preservation Breeding
    • Group Discounts
    • MORE FREE COURSES >
      • Quickie Genetics (Free!)
      • Heredity & Genetics (Free!)
      • Useful Genetics (Free!)
      • Basic Genetics Videos
  • Breed Preservation
    • Breed Status
    • Breeding for the future >
      • BFF Breed Groups
    • The "Elevator Pitch"
    • What's in the Gene Pool?
    • The Pox of Popular Sires
    • What population genetics can tell us about a breed
    • What population genetics can tell you...Tollers & Heelers
    • How to use kinship data
    • Using EBVs to breed better dogs >
      • How population size affects inbreeding
      • EBV Examples
    • How to read a dendrogram
    • Global Pedigree Project >
      • The Database
    • Finding the genes without DNA
    • How to read a heat map
  • Health Data
    • Bloat (Purdue Study)
    • Body Condition Score >
      • % Dysplastic vs BCS
    • Breed Comparions
    • Cancer
    • Cardiac
    • Cataracts
    • Caesareans
    • Deafness
    • Degenerative Myelopathy
    • Elbow Dysplasia
    • Epilepsy
    • Genetic Diversity
    • Genetic Diversity (MyDogDNA)
    • Hip Dysplasia >
      • Hip Dysplasia (Hou et al 2013)
    • Inbreeding Effects
    • Inbreeding (Gubbels)
    • Inbreeding (Dreger)
    • Lifespan
    • Litter size
    • Metabolic
    • mtDNA
    • Orthopedic
    • Mode of Inheritance
    • Patella Luxation
    • Thyroid
    • Portosystemic shunt
    • Purebred vs Mixed (UC Davis)
    • Purebred vs Mixed Breed (Bonnett)
    • Spay & Neuter Effects
    • Calboli et al 2008
    • Hodgman (1963)
    • Scott & Fuller (1965)
    • Stockard: Purebred crosses
    • Summers (2011)
  • Projects
    • How To Interpret Breed Analyses
    • Afghan Hound
    • More details about the Toller study
    • Belgian Tervuren >
      • Belgian Terv p2
      • Belgians- why population size matters
    • Bernese Mountain Dog
    • Boxer
    • Brussels Griffon
    • Bullmastiff
    • Canaan Dog >
      • Canaan analyses
    • Cesky Terrier >
      • Cesky genetic history
    • Chinook
    • Curly-coated Retriever
    • Doberman
    • Entelbucher Mountain Dog
    • Flatcoat Retriever
    • French Bulldog
    • German Shorthair
    • Golden Retriever >
      • Golden Retriever Pedigree Charts
    • Irish Water Spaniel >
      • IWS (6 Nov 17)
    • Labrador Retriever
    • Manchester Terrier
    • Mongolian Bankhar >
      • Research Updates
      • Bankhar 1
    • Norwegian Lundehund
    • Plummer Terrier
    • Otterhound
    • Portuguese Water Dog >
      • Portuguese Water Dog (pt 2)
    • Ridgeback
    • Schipperke
    • Standard Poodle >
      • The Problem With Poodles
      • 3poodle pedigree charts
      • 3Poodle Wycliff dogs
      • Poodle Genetics
    • Tibetan Spaniel
    • Tibetan Mastiff
    • West Highland White Terrier
    • Whippet
    • Wirehaired Pointing Griffons
    • UK KC Graphs >
      • UK KC Breed Status
      • UK Groups
      • KC Gundogs
      • KC Hounds
      • KC Terriers >
        • Terriers (select breeds)
      • KC Pastoral
      • KC Toys
      • KC Working
      • KC Utility
      • Australian KC
    • Breed outcrossing programs
  • Resources
    • Genetics Databases
    • Stud Books >
      • American Kennel Club stud books
      • Field Dog stud books
      • The Kennel Club (UK)
    • Learn
    • Videos about dog genetics
    • The Amazing Things Dogs Do! (videos) >
      • Livestock Management
      • Livestock guarding
      • Transportation, exploration, racing
      • Conservation & wildlife management
      • Detection Dogs
      • Medicine & Research
      • Entertainment
      • AKC/CHF Podcasts
    • Read & Watch
    • Bookshelf
  • Preventing Uterine Inertia

We need a Mayo Clinic for dog breeds

2/20/2022

 
By Carol Beuchat PhD
The Mayo Clinic is a non-profit medical institution in the United States that is famous for its integrated approach to solving difficult medical problems. Patients at the Mayo Clinic have usually run a gauntlet of medical specialists without success at cure, treatment, or even diagnosis. For these individuals, the Mayo Clinic is a last hope.

The Mayo Clinic is well known because it has been exceptionally good at solving the problems of the most difficult patients. It does this using an integrative approach to health care that might involve specialists in many fields that work together as a team to achieve diagnosis and treatment when specialists working independently have failed. Their extraordinary success using this integrated approach draws patients from around the world.

I think we need something comparable to the Mayo Clinic to help us address the growing burden of health issues in purebred dogs. Here's why.
Purebred dogs are plagued with a list of genetic disorders that numbers in the hundreds and grows longer every year. The costs to owners for veterinary treatment of breeds with high risk of disease are huge and growing, while at the same time millions of dollars are invested in research to understand, treat, or prevent these diseases. This burden of pain and suffering due to disease has caught the attention of animal welfare groups in several European countries, where legislation is being enforced that will restrict breeding of dogs that are likely to produce offspring with serious health issues. Norway has recently banned the breeding of English Bulldogs and Cavalier King Charles Spaniels in response to a lawsuit by an animal welfare group (scroll down the page at the link for English) on the grounds that the disorders common in the breeds cause a level of pain and suffering that violates Norway's Animal Welfare Act. For Bulldogs, the biggest problem is their brachycephalic skull (flattened face), which makes breathing difficult due Brachycephalic Obstructive Airway Sydrome (BOAS). It is likely that additional breeds will be added to those seen to be in violation of Norway's animal welfare laws. Furthermore, because there is similar legislation to protect the welfare of animals in countries around the world, the potential ramifications of enacting breeding bans on specific breeds are huge.
Picture
Breeding bans for violations of animal welfare laws are not designed to address the underlying problem, which is the high burden of diseases in purebred dogs. They simply prevent the production of animals that are likely to suffer. Managing and eliminating the health issues is left to breeders and purebred dog organizations such as kennel clubs. However, breeders lack the expertise, and often the will, to address these problems effectively. For example, breeders have been enthusiastic adopters of DNA testing to identify known mutations in their breeding stock, but the common assertion that a dog is healthy if it is "clear" of mutations is untrue. Furthermore, using this information properly can be tricky (e.g., mutation vs linkage tests), and advice from fellow breeders on Facebook can run the gamut from factual and informative to just plain wrong. In any case, because dogs surely have many more mutations than we know about and can test for, DNA testing will not make dogs healthier because they are so specific. For instance, a breeder that dutifully runs the available mutation tests, then breeds to a popular sire, is simply exchanging a known risk with an unknown one.

Faced with a health issue, the temptation of breeders is usually to assume that it is caused by a gene, with the result that they identify individual issues and search for solutions, one problem at a time. If a genetic disorder pops up in a breed, the scenario would be to search for the mutation, develop a mutation test that can be used on individual dogs, then avoid breeding dogs together that share the same mutations. This strategy can be effective if the disorder is caused by a single recessive mutation, but many problems are not; for these, affected animals and maybe also their relatives are removed from the breeding population on the assumption that there is some underlying genetic cause that should not be perpetuated. Breeders have been trying to manage many disorders this way, such as epilepsy, cancer, and renal dysplasia, but with little success. The consequence is that dogs (and their genes) are removed from the breeding stock, which reduces the size of the breeding population and increases the rate of inbreeding, both of which act to increase the expression of genetic disorders. Thus, breeds are stuck in a loop in which the actions of breeders to reduce the risk of genetic disorders actually increases the likelihood that some other issue will appear. It's an endless game of genetic whack-a-mole that is slowly driving breeds closer and closer to point where genetic deterioration will be severe enough that the breed goes extinct.

There are breeds that appear to already be at this extinction point. A very high percentage of Dobermans die of fatal DCM (degenerative cardiomyopathy), and recently the trend has been towards deaths in younger and younger dogs.  Flatcoated Retrievers and Bernese Mountain Dogs rarely live past middle age, because they are stricken down by cancer. Most Cavalier King Charles Spaniels will suffer from mitral valve disease, and an early onset form of the disease takes dogs in their prime (Lewis et al 2011). Upwards of 70% of Cavaliers are also the victims of painful neurological conditions, Syringomyelia and Chiari Formation, which are also becoming increasingly common in other breeds with shortened muzzles and a tendency towards domed skulls (e.g., French Bulldogs, Brussels Griffons, Chihuahua). For these breeds and many others, the health issues common in the breed challenge the ethics of continuing to breed them.
We will not begin to stem the tide of health issues in purebred dogs by doing more of what we already do. In response to the ruling by the Norwegian court that banned the breeding of Cavaliers and Bulldogs, the Norwegian Kennel Club said that it would continue to work with breeders to improve breed health through health requirements for breeding and other undefined measures. Similar statements supporting the Norwegian Kennel Club's position were forthcoming from the FCI, Australia, and other kennel clubs around the world. Breeders and kennel clubs are going to double down.

What is missing in these statements is the recognition that the underlying problem is not with the genetics of individual dogs, but rather it is a problem of genetics across the breed. For many decades, most purebred dog breeds have been part of a registration system that is strictly closed to the introduction of dogs from unregistered parents. The result is a genetically closed population, a group of animals trapped on a genetically isolated island. All individuals are necessarily related, having descended from the same original genetic founders, so all breeding will be to a relative. Each breed is a genetically closed population from which genes can be lost through selective breeding or just by chance, but the genes lost cannot be replaced because of the closed registry. The result is that the gene pool shrinks relentlessly, and the population becomes more and more inbred. Eventually, genetically closed populations, like those of purebred dogs, suffer an increasing burden of health problems, low fertility, and shortened lifespan until, eventually, they simply go extinct. This is the road most breeds are on, and the kennel clubs have said nothing in their recent statements about the breeding ban in Norway that suggests a plan to change this trajectory. In fact, doing more of the same, even harder and more carefully, will actually make things worse.
We have a complex problem to solve, one which the stakeholders - breeders and clubs - are simply not equipped to address. Each breed has its own unique set of issues, and our current strategy is to focus on one or a few of these at a time. However, it's not the individual problems that need to be addressed, but the underlying cause, which is common to all breeds. Purebred dogs are trapped in closed gene pools that force inbreeding. We will not solve the health problems in dogs until we abandon the closed stud book that prevents replacement of genes that are systematically lost every generation. 

Opening the stud books would slow the pace of new problems, but restoring health to the many breeds that are badly damaged will require a systematic and well-planned strategy. Unfortunately, however, there is nowhere for breeders to go for help.


Here is where I think we need something for dog breeds that is comparable to the Mayo Clinic. Note that I specified "dog breeds" and not individual dogs. The health problems of dogs are a consequence of the genetic health and structure of the population of animals in the breed, and the solution must first be directed at the breed population, not the individual dogs. The approach must be integrated and specific for the circumstances of each breed. Coming up with the right plan will require a broad range of expertise.

The genetic rescue of the Norwegian Lundehund has taken this approach. Inbreeding of the Lundehund is 80%, the highest ever recorded in a dog (perhaps also in any mammal?!!), and the breed suffers from extremely low fertility and a gastrointestinal disorder than can be fatal. Before designing a breeding plan for genetic rescue, a team of scientists performed genetic analyses on the pedigree database and another team analyzed genotypes of both the Lundehund and breeds identified as potential candidates for cross breeding. Using demographic information, genetic modeling showed how different breeding strategies would affect the efficiency of a breeding program, e.g., how many animals would be required and how long would it take for gains in genetic diversity. Each animal used and produced is evaluated for health and relevant traits, and additional breedings are planned based on the parameters of the genetic model being followed. Done properly, with good scientific oversight, a genetic rescue program like this can demonstrate the effectiveness of the breeding strategy in two generations. For the Lundehund, the second generation backcross has produced healthy animals of good  type that also carry new genetic diversity that can be integrated into the breed population. 
To tackle the health issues of purebred dogs, we need to take an integrative approach. The diseases in individual dogs reflect choices made by breeders, constraints on breeding options imposed by the closed gene pool, division of gene pools based on geography, different preferences for type, the varied purposes for which the dogs are bred (show, working, pet), how breeders are choosing to manage genetic health issues, and many other things. The issues will vary by breed, as will the potential solutions. Tackling these problems will require the expertise of teams of scientists that can work out the critical problems and the range of practical options for addressing them. There will need to be tracking of animals and followup, periodic evaluation of progress, tending of pedigree databases and genotype data, and (perhaps most important of all) education of breeders so they can be full participants in the solutions for their breeds and have the knowledge to carry the breed forward with oversight when genetic restoration is successful.

A place like this does not exist, yet it is desperately needed now, to help breeders tackle health problems before more breeding bans are imposed on potentially dozens of breeds. Cornell University, my alma mater (PhD.), recently received a $30 million gift to launch the Cornell Margaret and Richard Riney Canine Health Center at the university's excellent veterinary school. Another gift of $12 million will establish the Duffield Institute of Animal Behavior at Cornell. These funds fortify what already was a strong concentration of resources in canine health and genetics at Cornell. But neither will address what is arguably the most pressing issue affecting the health of dogs: the burden of genetic disorders that result from traditional but outdated breeding practices and ineffective strategies for preventing disease. ​While disease research has improved our understanding of the illnesses suffered by dogs, it rarely has substantial impact on health because it doesn't alter the landscape of underlying issues that result in the production of genetic disease in the first place. To make a difference, we need an approach that focuses not just on the dogs, but also on the breeders. Breeders need access to education, to up-to-date data about the genetic status of their breed, and (especially) to expert guidance to replace the blizzard of opinions available on Facebook as a source of factual, relevant information.
Many breeds are now or will soon be at a crossroads - they must solve the serious health problems in the breed or face a ban on breeding. Addressing these problems will require creation of something similar to what I have described here, and it will require a significant initial investment, one that breeders will likely be unable to meet. Philanthropy can recognize the health problems of dogs because they are visible; it it harder to see the connection of the health problems to the underlying issues of inbreeding, closed gene pools, traditional but outdated breeding strategies, and misunderstandings about the proper use of DNA testing.

I don't see the problems facing dogs and their breeders being solved without a Mayo Clinic-like institution where a concentration of expertise can tease apart the layers of issues that must be addressed in order to restore dog breeds to health.

We know that genetic rescue is possible, but the infrastructure necessary to do it for more than a breed or two at a time simply doesn't exist. We know what we need to build if we can find the resources. The challenge now is to identify those that have a commitment to improving the health of dogs and can help pull together the resources to move this forward. 


To learn more about the genetics of dogs, check out
ICB's online courses

***************************************

Visit our Facebook Groups

ICB Institute of Canine Biology
...the latest canine news and research

ICB Breeding for the Future
...the science of animal breeding

Comments are closed.

    Archives

    January 2025
    November 2022
    July 2022
    May 2022
    April 2022
    March 2022
    February 2022
    November 2021
    October 2021
    December 2020
    January 2020
    August 2019
    July 2019
    June 2019
    May 2019
    April 2019
    March 2019
    February 2019
    January 2019
    December 2018
    November 2018
    September 2018
    August 2018
    July 2018
    June 2018
    May 2018
    October 2017
    August 2017
    May 2017
    April 2017
    March 2017
    February 2017
    January 2017
    December 2016
    November 2016
    September 2016
    August 2016
    July 2016
    June 2016
    April 2016
    March 2016
    February 2016
    January 2016
    December 2015
    November 2015
    October 2015
    September 2015
    August 2015
    July 2015
    June 2015
    May 2015
    April 2015
    March 2015
    January 2015
    December 2014
    November 2014
    October 2014
    September 2014
    August 2014
    July 2014
    June 2014
    May 2014
    February 2014
    December 2013
    October 2013
    September 2013
    July 2013
    March 2013
    July 2012
    April 2012

    Categories

    All
    Behavior
    Border-collie
    Herding

Blog

News


About Us

Contact Us








Copyright © 2012-2017 Institute of Canine Biology
Picture
Picture